Potent and selective Kunitz domain inhibitors of plasma kallikrein designed by phage display.

@article{Dennis1995PotentAS,
  title={Potent and selective Kunitz domain inhibitors of plasma kallikrein designed by phage display.},
  author={Mark S. Dennis and A S Herzka and Robert A. Lazarus},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 43},
  pages={25411-7}
}
Phage displaying APPI Kunitz domain libraries have been used to design potent and selective active site inhibitors of human plasma kallikrein, a serine protease that plays an important role in both inflammation and coagulation. Selected clones from two Kunitz domain libraries randomized at or near the binding loop (positions 11-13, 15-19, and 34) were sequenced following five rounds of selection on immobilized plasma kallikrein. Invariant preferences for Arg at position 15 and His at position… CONTINUE READING

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