Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists.

  title={Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists.},
  author={Sari Yrj{\"o}l{\"a} and Teija Parkkari and Dina Navia-Paldanius and Tuomo Laitinen and Agnieszka A. Kaczor and Tarja Kokkola and Frank Adusei-Mensah and Juha R. Savinainen and Jarmo T. Laitinen and Antti Poso and Amy Alexander and June Penman and Lisa M. Stott and Marie Anskat and Andrew J. Irving and Tapio J. Nevalainen},
  journal={European journal of medicinal chemistry},
To date, many known G protein-coupled receptor 55 (GPR55) ligands are those identified among the cannabinoids. In order to further study the function of GPR55, new potent and selective ligands are needed. In this study, we utilized the screening results from PubChem bioassay AID 1961 which reports the results of Image-based HTS for Selective Agonists of GPR55. Three compounds, CID1792579, CID1252842 and CID1011163, were further evaluated and used as a starting point to create a series of… CONTINUE READING