Corpus ID: 82375429

Potent and selective ABCG2 inhibitors derived from tariquidar

  title={Potent and selective ABCG2 inhibitors derived from tariquidar},
  author={C. Puentes},
  • C. Puentes
  • Published 2013
  • Chemistry
  • Three different classes of selective ABCG2 modulator (BCRP, breast cancer resistance protein) derived from the lead structure tariquidar have been prepared in this thesis. In chapters one and two the solid phase synthesis approach was used to obtain new derivatives of the lead structure and two different methodologies were developed. A very simple, effective and straightforward method of synthesis using Wang resing as solid support was developed in chapter one. A small library of new tariquidar… CONTINUE READING

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