Potent and conditional redirected T cell killing of tumor cells using Half DVD-Ig

@inproceedings{Bardwell2017PotentAC,
  title={Potent and conditional redirected T cell killing of tumor cells using Half DVD-Ig},
  author={Philip D. Bardwell and Matthew M. Staron and Junjian Liu and Qingfeng Tao and Susanne Scesney and Gail T Bukofzer and Luis E. Rodriguez and Chee-Ho Choi and Jennifer P. Wang and Qing Chang and Feng Dong and Cherrie K. Donawho and Jieyi Wang and Christine M. Grinnell and Edit Tarcsa and Charles W. Hutchins and Tariq Ghayur and Jijie Gu},
  booktitle={Protein & Cell},
  year={2017}
}
Novel biologics that redirect cytotoxic T lymphocytes (CTLs) to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However, the ability to safely and potently target CD3 on CTL toward tumor associated antigens (TAA) expressed on tumor cells remains a challenge of both technology and biology. Herein we describe the use of a… CONTINUE READING