Potent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma

@inproceedings{Huang2014PotentAS,
  title={Potent and Selective Double-Headed
Thiophene-2-carboximidamide
Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of
Melanoma},
  author={He Huang and Huiying Li and Sun Yang and Georges Chreifi and P Martasek and Linda J. Roman and Frank L. Meyskens and Thomas L Poulos and Richard B Silverman},
  booktitle={Journal of medicinal chemistry},
  year={2014}
}
Selective inhibitors of neuronal nitric oxide synthase (nNOS) are regarded as valuable and powerful agents with therapeutic potential for the treatment of chronic neurodegenerative pathologies and human melanoma. Here, we describe a novel hybrid strategy that combines the pharmacokinetically promising thiophene-2-carboximidamide fragment and structural features of our previously reported potent and selective aminopyridine inhibitors. Two inhibitors, 13 and 14, show low nanomolar inhibitory… CONTINUE READING

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