Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII.

@article{Cau2017PotentAS,
  title={Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII.},
  author={Ylenia Cau and Daniela Vullo and Mattia Mori and Elena Dreassi and Claudiu T. Supuran and Maurizio Botta},
  journal={Molecules},
  year={2017},
  volume={23 1}
}
Selective inhibition of tumor-associated carbonic anhydrase (CA; EC 4.2.1.1) isoforms IX and XII is a crucial prerequisite to develop successful anticancer therapeutics. Herein, we confirmed the efficacy of the 3-nitrobenzoic acid substructure in the design of potent and selective carboxylic acid derivatives as CAs inhibitors. Compound 10 emerged as the… CONTINUE READING