Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo.


The Wnt pathway is an evolutionarily conserved and tightly regulated signaling network with important roles in embryonic development and adult tissue regeneration. Impaired Wnt pathway regulation, arising from mutations in Wnt signaling components, such as Axin, APC, and β-catenin, results in uncontrolled cell growth and triggers oncogenesis. To explore the… (More)
DOI: 10.1021/acsmedchemlett.5b00452


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