Potent and Non-Cytotoxic Antibacterial Compounds against Methicillin-Resistant Staphylococcus aureus Isolated from Psiloxylon mauritianum, A Medicinal Plant from Reunion Island

  title={Potent and Non-Cytotoxic Antibacterial Compounds against Methicillin-Resistant Staphylococcus aureus Isolated from Psiloxylon mauritianum, A Medicinal Plant from Reunion Island},
  author={Jonathan Sorres and Amandine Andr{\'e} and Elsa Van Elslande and Didier Stien and V{\'e}ronique Eparvier},
With the occurrence of antibiotic-resistant Staphylococcus aureus strains, identification of new anti-staphylococcal drugs has become a necessity. It has long been demonstrated that plants are a large and diverse source of antibacterial compounds. Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, was chemically investigated for its reported biological activity against S. aureus. Aspidin VB, a phloroglucinol derivative never before described, together with Aspidin BB, were… 

Phloroglucinol and Its Derivatives: Antimicrobial Properties toward Microbial Pathogens.

This review focuses on the use of PG and its derivatives to control microbial infection and the underlying mechanism of action and some of the various alternative strategies, such as the use in conjugation, nanoformulation, antibiotic combination, and encapsulation are thoroughly discussed.

Aqueous Extract of Psiloxylon mauritianum, Rich in Gallic Acid, Prevents Obesity and Associated Deleterious Effects in Zebrafish

The aqueous extract of P. mauritianum exhibited “anti-weight-gain” properties, which prevented the development of obesity and its deleterious effects at the peripheral and central levels.



Anti-staphylococcal plant natural products.

The activities described here show that there are many potential new classes of anti-staphylococcal agents which should undergo further cytotoxicity, microbial specificity and preclinical in vivo studies to assess their potential.

The Polyphenol-Rich Extract from Psiloxylon mauritianum, an Endemic Medicinal Plant from Reunion Island, Inhibits the Early Stages of Dengue and Zika Virus Infection

An extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the infection of ZIKV in vitro without exhibiting cytotoxic effects and may be of value for identifying and characterizing antiviral compounds to fight medically-important flaviviruses.

Investigation of antibacterial activity of aspidin BB against Propionibacterium acnes

The obtained data highlighted the potential of using aspidin BB as an alternative treatment for acne vulgaris because of its strong antibacterial activity and the effective constituents of D. fragrans (L.) Schott to treat acne might be phloroglucinol derivatives including aspidIn BB, aspid in PB, as pidinol and dryofragin.

The importance of the development of antibiotic resistance in Staphylococcus aureus.

  • G. Schito
  • Medicine, Biology
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 2006
The recent emergence of MRSA infections in the community, affecting patients with no established risk factors for MRSA acquisition, is likely to impact significantly on future strategies for control of nosocomial MRSA.

EUCAST definitive document EDef 7.1: method for the determination of broth dilution MICs of antifungal agents for fermentative yeasts.

The method described in this document is intended for testing the susceptibility ofYeasts that cause clinically significant infections (primarily Candida spp.), and encompasses only those yeasts that are able to ferment glucose.

Waves of resistance: Staphylococcus aureus in the antibiotic era

The molecular epidemiology of the epidemic waves of peniillin- and methicillin-resistant strains of S. aureus that have occurred since 1940 are reviewed, with a focus on the clinical and molecular epidemiological of CA-MRSA.

Ichthyotoxic phloroglucinol derivatives from Dryopteris fragrans and their anti-tumor promoting activity.

Two new ichthyotoxic compounds, aspidin PB (8) and dryofragin (9), along with three known phloroglucinol derivatives (1-3) and five terpenoids, were isolated from the whole herbs of Dryopteris

Psiloxylon mauritianum (Bouton ex Hook.f.) Baillon (Myrtaceae): A promising traditional medicinal plant from the Mascarene Islands

The present monograph has tried to establish the botanical description, traditional uses and the main constituents identified from PM (Bouton ex Hook.f.) Baillon to appraise the therapeutic potential of this medicinal plant against infectious diseases.