Potent analgesic and anti-inflammatory actions of a novel thymulin-related peptide in the rat.

@article{SafiehGarabedian2002PotentAA,
  title={Potent analgesic and anti-inflammatory actions of a novel thymulin-related peptide in the rat.},
  author={Bared Safieh-Garabedian and Mireille Dardenne and Jean Marie Pl{\'e}au and Nayef E. Saad{\'e}},
  journal={British journal of pharmacology},
  year={2002},
  volume={136 6},
  pages={947-55}
}
1. The present study examines the effect of PAT (peptide analogue of thymulin) in two rat models of inflammatory hyperalgesia induced by either i.pl. (1.25 microg in 50 microl saline) or i.p. (50 microg in 100 microl) injections of endotoxin ET. 2. Pretreatment with PAT (1, 5 or 25 microg in 100 microl saline, i.p.) decreased, in a dose dependent manner, both mechanical hyperalgesia, determined by the paw pressure (PP) test and thermal hyperalgesia determined by the hot plate (HP), the paw… CONTINUE READING

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