Potent adjuvant effects of novel NKT stimulatory glycolipids on hemagglutinin based DNA vaccine for H5N1 influenza virus.

@article{Hung2014PotentAE,
  title={Potent adjuvant effects of novel NKT stimulatory glycolipids on hemagglutinin based DNA vaccine for H5N1 influenza virus.},
  author={Jung-Tung Hung and Yi-Chieh Tsai and Wen-Der Lin and J Y Jan and Kun-Hsien Lin and Junying Huang and J C Cheng and Ming-wei Chen and C. -H. Wong and Alice Yu},
  journal={Antiviral research},
  year={2014},
  volume={107},
  pages={
          110-8
        }
}
H5N1 influenza virus is a highly pathogenic virus, posing a pandemic threat. Previously, we showed that phenyl analogs of α-galactosylceramide (α-GalCer) displayed greater NKT stimulation than α-GalCer. Here, we examined the adjuvant effects of one of the most potent analogs, C34, on consensus hemagglutinin based DNA vaccine (pCHA5) for H5N1 virus. Upon intramuscular electroporation of mice with pCHA5 with/without various α-GalCer analogs, C34-adjuvanted group developed the highest titer… CONTINUE READING
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