Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action

@article{Kawahata2013PotentAO,
  title={Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action},
  author={I. Kawahata and Masaaki Yoshida and Wen-Xian Sun and A. Nakajima and Y. Lai and Naoya Osaka and K. Matsuzaki and A. Yokosuka and Y. Mimaki and A. Naganuma and Y. Tomioka and T. Yamakuni},
  journal={Journal of Neural Transmission},
  year={2013},
  volume={120},
  pages={1397-1409}
}
AbstractcAMP/PKA/ERK/CREB signaling linked to CRE-mediated transcription is crucial for learning and memory. We originally found nobiletin as a natural compound that stimulates this intracellular signaling and exhibits anti-dementia action in animals. Citrus reticulata or C.unshiu peels are employed as “chinpi” and include a small amount of nobiletin. We here provide the first evidence for beneficial pharmacological actions on the cAMP/PKA/ERK/CREB cascade of extracts from nobiletin-rich C… Expand
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