Potent activation of the human tandem pore domain K channel TRESK with clinical concentrations of volatile anesthetics.

@article{Liu2004PotentAO,
  title={Potent activation of the human tandem pore domain K channel TRESK with clinical concentrations of volatile anesthetics.},
  author={Canhui Liu and John D Au and Hilary Liao Zou and Joseph F. Cotten and Charles Spencer Yost},
  journal={Anesthesia and analgesia},
  year={2004},
  volume={99 6},
  pages={1715-22, table of contents}
}
The tandem pore domain K channel family mediates background K currents present in excitable cells. Currents passed by certain members of the family are enhanced by volatile anesthetics, thus suggesting a novel mechanism of anesthesia. The newest member of the family, termed TRESK (TWIK [tandem pore domain weak inward rectifying channel]-related spinal cord K channel), has not been studied for anesthetic sensitivity. We isolated the coding sequence for TRESK from human spinal cord RNA and… CONTINUE READING

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Tandem pore (2P) domain K channels as anesthetic targets

  • CS Yost, CH Kindler
  • 2002
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