Potent activation of antigen-specific T cells by antigen-loaded nanospheres.

@article{Wang2005PotentAO,
  title={Potent activation of antigen-specific T cells by antigen-loaded nanospheres.},
  author={Xin Wang and Tomofumi Uto and Katsuaki Sato and Keiko Ide and Takami Akagi and Mika Okamoto and Tatsuo Kaneko and Mitsuru Akashi and M. Baba},
  journal={Immunology letters},
  year={2005},
  volume={98 1},
  pages={
          123-30
        }
}
Polystyrene nanospheres (NS) were found to be efficiently taken up by murine antigen-presenting cells (APC), especially bone marrow-derived dendritic cells (DC), in vitro and in vivo. The efficiency of NS uptake was not affected by the maturation state of DC. Both immature and mature DC had similar ability to take up NS in a dose- and time-dependent manner. Uptake and intracellular localization of NS was clearly demonstrated by confocal laser microscopy, using NS with fluorescence. DC could… CONTINUE READING