Potent V2 vasopressin antagonists with structural changes at their C-terminals.

@article{Sawyer1988PotentVV,
  title={Potent V2 vasopressin antagonists with structural changes at their C-terminals.},
  author={Wilbur H. Sawyer and Krzysztof Bańkowski and Aleksandra Misicka and Eleonora Nawrocka and M. Kruszyński and Stoytcho Stoev and Wieslaw A Klis and Jerry Przybylski and Maurice Manning},
  journal={Peptides},
  year={1988},
  volume={9 1},
  pages={157-63}
}
A variety of structural changes were made in the C-terminals of four potent antidiuretic (V2) antagonists. The parent analogs were all derivatives of [1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)]arginine-vasopressin, d(CH2)5AVP, namely d(CH2)5[D-Phe2,Ile4]AVP, d(CH2)5[D-Ile2,Ile4]AVP, d(CH2)5[D-Tyr(Et)2, Val4]AVP and d(CH2)5[D-Tyr(Et)2… CONTINUE READING