Potent T cell response to a class I-binding 13-mer viral epitope and the influence of HLA micropolymorphism in controlling epitope length.

@article{Green2004PotentTC,
  title={Potent T cell response to a class I-binding 13-mer viral epitope and the influence of HLA micropolymorphism in controlling epitope length.},
  author={Kate J. Green and John James Miles and Judy T. Tellam and Wendy J M van Zuylen and Geoff Connolly and Jacqueline M. Burrows},
  journal={European journal of immunology},
  year={2004},
  volume={34 9},
  pages={
          2510-9
        }
}
The BZLF1 antigen of Epstein-Barr virus includes three overlapping sequences of different lengths that conform to the binding motif of human leukocyte antigen (HLA) B*3501. These 9-mer (56LPQGQLTAY64), 11-mer (54EPLPQGQLTAY64), and 13-mer (52LPEPLPQGQLTAY64) peptides all bound well to B*3501; however, the CTL response in individuals expressing this HLA allele was directed strongly and exclusively towards the 11-mer peptide. In contrast, EBV-exposed donors expressing HLA B*3503 showed no… CONTINUE READING
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