Potent Potentiating Diuretic Effects of Prednisone in Congestive Heart Failure

@article{Liu2006PotentPD,
  title={Potent Potentiating Diuretic Effects of Prednisone in Congestive Heart Failure},
  author={Chao Liu and Hua Chen and Caixia Zhou and Zhen-guo Ji and Gang Liu and Yanqiu Gao and L. Tian and L. Yao and Ye Zheng and Qingzhen Zhao and Kunshen Liu},
  journal={Journal of Cardiovascular Pharmacology},
  year={2006},
  volume={48},
  pages={173-176}
}
Abstract: Animal studies showed glucocorticoids could specifically dilate renal vasculature, regulate synthesis and release of atrial natriuretic peptide (ANP), upregulate ANP receptors on vascular endothelial cells, and thus have potent potentiating diuresis and natriuresis effects in animal studies; however, their diuretic efficacy in humans is yet to be known. Therefore, we designed this randomized, double- blind, placebo-controlled, clinical study to determine the diuretic efficacy of… 

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Effect of Corticosteroid on Renal Water and Sodium Excretion in Symptomatic Heart Failure: Prednisone for Renal Function Improvement Evaluation Study

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Glucocorticoids completely reverse refractory diuretic resistance in a patient with decompensated heart failure and gross edema

The use of glucocorticoids is reported to reverse refractory diuretic resistance in a congestive heart failure patient who failed with intravenous administration of a high dose of furosemide (1000 mg/ day).

Prednisone adding to usual care treatment for refractory decompensated congestive heart failure.

Adding prednisone to conventional care in the patients with refractory DCHF induced potent diuresis accompanied by a dramatic relief of congestive symptoms and improvements in clinical status and renal function.

Hormone treatments in congestive heart failure

  • L. LeiY. Mao
  • Biology, Medicine
    The Journal of international medical research
  • 2018
Clinical trials indicate that in CHF patients with low insulin-like growth factor-1 or low thyroid hormone levels, supplemental treatment with growth hormone or thyroid hormone seems to be cardioprotective; and in CHf patients with volume overload the vasopressin antagonists can relieve the symptoms superior to loop diuretics.

Why Do Glucocorticoids Produce Potent and Persistent Diuresis Only in Subjects with Volume Overload Other Than Euvolemia

The diuresis induced by glucocorticoids was systemic volume dependent, which explained the phenomenon that glucoc Corticoids only have potent and persistent diuretic effect in congestive heart failure.

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FIGURE 2. An example of using prednisone as a potentiating diuretic agent in a patient with idiopathic dilated cardiomyopathy with significant fluid retention