Potent Potentiating Diuretic Effects of Prednisone in Congestive Heart Failure

@article{Liu2006PotentPD,
  title={Potent Potentiating Diuretic Effects of Prednisone in Congestive Heart Failure},
  author={Chao Liu and Hua Bin Chen and Caixia Zhou and Zhen-guo Ji and Gang Liu and Yanqiu Gao and L. Tian and L. Yao and Ye Zheng and Qingzhen Zhao and Kunshen Liu},
  journal={Journal of Cardiovascular Pharmacology},
  year={2006},
  volume={48},
  pages={173-176}
}
Abstract: Animal studies showed glucocorticoids could specifically dilate renal vasculature, regulate synthesis and release of atrial natriuretic peptide (ANP), upregulate ANP receptors on vascular endothelial cells, and thus have potent potentiating diuresis and natriuresis effects in animal studies; however, their diuretic efficacy in humans is yet to be known. Therefore, we designed this randomized, double- blind, placebo-controlled, clinical study to determine the diuretic efficacy of… Expand

Paper Mentions

Interventional Clinical Trial
We designed this, randomized, double-blind, placebo-controlled trial to determine the clinical efficacy of chronic administration of prednisone on renal function and clinical… Expand
ConditionsHeart Failure, Congestive
InterventionDrug
Potent diuretic effects of prednisone in heart failure patients with refractory diuretic resistance.
TLDR
It is demonstrated that prednisone can rapidly eliminate volume overload and improve clinical status and renal function in CHF patients with diuretic resistance. Expand
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Limited data indicate that glucocorticoid therapy may be used safely in patients with acute decompensated heart failure in short term, and there was a remarkable SCr reduction after 7 days treatment. Expand
Effect of Corticosteroid on Renal Water and Sodium Excretion in Symptomatic Heart Failure: Prednisone for Renal Function Improvement Evaluation Study
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Only low-dose prednisone significantly enhanced urine output and renal sodium excretion, and high-dose Prednisone induced a more potent natriuresis and diuresis induced byprednisone. Expand
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TLDR
Prednisone might be useful for short-term SUA-lowering in CHF patients with hyperuricemia and allopurinol greatly lowered SUA rapidly, and participants treated with prednisone had an improvement in clinical status. Expand
Effects of glucocorticoids in potentiating diuresis in heart failure patients with diuretic resistance.
TLDR
This review tries to summarize the available evidence and potential mechanisms related to glucocorticoid therapy in patients with heart failure and its effect on diuretic resistance. Expand
Glucocorticoids completely reverse refractory diuretic resistance in a patient with decompensated heart failure and gross edema
TLDR
The use of glucocorticoids is reported to reverse refractory diuretic resistance in a congestive heart failure patient who failed with intravenous administration of a high dose of furosemide (1000 mg/ day). Expand
Prednisone adding to usual care treatment for refractory decompensated congestive heart failure.
TLDR
Adding prednisone to conventional care in the patients with refractory DCHF induced potent diuresis accompanied by a dramatic relief of congestive symptoms and improvements in clinical status and renal function. Expand
The glucocorticoid in acute decompensated heart failure: Dr Jekyll or Mr Hyde?
TLDR
It is suggested that in a patient with ADHF and congestion resistant to diuretic therapy, glucocorticoid administration is safe and associated with improvement in congestion, neurohormonal status, and renal function. Expand
Hormone treatments in congestive heart failure
  • L. Lei, Y. Mao
  • Medicine
  • The Journal of international medical research
  • 2018
TLDR
Clinical trials indicate that in CHF patients with low insulin-like growth factor-1 or low thyroid hormone levels, supplemental treatment with growth hormone or thyroid hormone seems to be cardioprotective; and in CHf patients with volume overload the vasopressin antagonists can relieve the symptoms superior to loop diuretics. Expand
Why Do Glucocorticoids Produce Potent and Persistent Diuresis Only in Subjects with Volume Overload Other Than Euvolemia
TLDR
The diuresis induced by glucocorticoids was systemic volume dependent, which explained the phenomenon that glucoc Corticoids only have potent and persistent diuretic effect in congestive heart failure. Expand
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FIGURE 2. An example of using prednisone as a potentiating diuretic agent in a patient with idiopathic dilated cardiomyopathy with significant fluid retention