Potent Neuroprotective Properties against the Alzheimer β-Amyloid by an Endogenous Melatonin-related Indole Structure, Indole-3-propionic Acid*

@article{Chyan1999PotentNP,
  title={Potent Neuroprotective Properties against the Alzheimer $\beta$-Amyloid by an Endogenous Melatonin-related Indole Structure, Indole-3-propionic Acid*},
  author={Y J Chyan and B Poeggeler and Rawhi A. Omar and Daniel G. Chain and Blas Frangione and Jorge Ghiso and Miguel A. Pappolla},
  journal={The Journal of Biological Chemistry},
  year={1999},
  volume={274},
  pages={21937 - 21942}
}
Widespread cerebral deposition of a 40–43-amino acid peptide called the amyloid β-protein (Aβ) in the form of amyloid fibrils is one of the most prominent neuropathologic features of Alzheimer’s disease. Numerous studies suggest that Aβ is toxic to neurons by free radical-mediated mechanisms. We have previously reported that melatonin prevents oxidative stress and death of neurons exposed to Aβ. In the process of screening indole compounds for neuroprotection against Aβ, potent neuroprotective… Expand
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