Potent CYP3A4 inhibitory constituents of Piper cubeba.

  title={Potent CYP3A4 inhibitory constituents of Piper cubeba.},
  author={Tepy Usia and Tadashi Watabe and Shigetoshi Kadota and Yasuhiro Tezuka},
  journal={Journal of natural products},
  volume={68 1},
The EtOAc-soluble fraction of the water extract of Piper cubeba, having shown potent inhibitory activity on the metabolism mediated by CYP3A4, was subjected to activity-guided isolation to yield two new lignans, (8R,8'R)-4-hydroxycubebinone (1) and (8R,8'R,9'S)-5-methoxyclusin (2), and two new sesquiterpenes, (5 alpha,8 alpha)-2-oxo-1(10),3,7(11)-guaiatrien-12,8-olide (3) and (1 alpha,2 beta,5 alpha,8 alpha 10 alpha)-1,10-epoxy-2-hydroxy-3,7(11)-guaiadien-12,8-olide (4), along with 16 known… CONTINUE READING

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