Potent Anti-hepatitis C Virus (HCV) T Cell Immune Responses Induced in Mice Vaccinated with DNA-Launched RNA Replicons and Modified Vaccinia Virus Ankara-HCV.

@article{Marn2019PotentAC,
  title={Potent Anti-hepatitis C Virus (HCV) T Cell Immune Responses Induced in Mice Vaccinated with DNA-Launched RNA Replicons and Modified Vaccinia Virus Ankara-HCV.},
  author={Mar{\'i}a Isabel Quintana Mar{\'i}n and Patricia Marques Perez and K. J. Ljungberg and Carlos Oscar S{\'a}nchez Sorzano and Carmen Elena G{\'o}mez and Peter Liljestr{\"o}m and Mariano Rodr{\'i}guez Esteban and Juan Garc{\'i}a-Arriaza},
  journal={Journal of virology},
  year={2019},
  volume={93 7}
}
Hepatitis C is a liver disease caused by the hepatitis C virus (HCV) affecting 71 million people worldwide with no licensed vaccines that prevent infection. Here, we have generated four novel alphavirus-based DNA-launched self-amplifying RNA replicon (DREP) vaccines expressing either structural core-E1-E2 or nonstructural p7-NS2-NS3 HCV proteins of genotype 1a placed under the control of an alphavirus promoter, with or without an alphaviral translational enhancer (grouped as DREP-HCV or DREP-e… CONTINUE READING
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