Potent Anti-Tumor Effect Generated by a Novel Human Papillomavirus (HPV) Antagonist Peptide Reactivating the pRb/E2F Pathway

@inproceedings{Guo2011PotentAE,
  title={Potent Anti-Tumor Effect Generated by a Novel Human Papillomavirus (HPV) Antagonist Peptide Reactivating the pRb/E2F Pathway},
  author={Cai-ping Guo and Ke-wei Liu and Hai-bo Luo and Hongbo Chen and Yi cheng Zheng and Shen-nan Sun and Qian Zhang and Laiqiang Huang},
  booktitle={PloS one},
  year={2011}
}
Human papillomavirus type 16 (HPV16) E7 is a viral oncoprotein believed to play a major role in cervical cancer. In this study, an antagonist peptide against HPV16E7 protein was first identified from screening the c7c phage display peptide library. The binding specificity and affinity of the selected peptide to HPV16E7 were tested by competitive enzyme-linked immunosorbent assay (ELISA). The antagonist peptide showed obvious anti-tumor efficacy both in cell lines and animal tumor models… CONTINUE READING