Potency values from the local lymph node assay: application to classification, labelling and risk assessment.

  title={Potency values from the local lymph node assay: application to classification, labelling and risk assessment.},
  author={Scott E Loveless and A P Api and Ren{\'e} Wilfrid Robert Crevel and Eric Debruyne and Armin O. Gamer and Ian R Jowsey and Petra Kern and I A N Kimber and L. G. Lea and Paulette Lloyd and Zoonia Mehmood and Winfried Steiling and Gauke Veenstra and Michael M Woolhiser and Christa Hennes},
  journal={Regulatory toxicology and pharmacology : RTP},
  volume={56 1},
Hundreds of chemicals are contact allergens but there remains a need to identify and characterise accurately skin sensitising hazards. The purpose of this review was fourfold. First, when using the local lymph node assay (LLNA), consider whether an exposure concentration (EC3 value) lower than 100% can be defined and used as a threshold criterion for classification and labelling. Second, is there any reason to revise the recommendation of a previous ECETOC Task Force regarding specific EC3… CONTINUE READING
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