Potency of select statin drugs in a new mouse model of hyperlipidemia and atherosclerosis.

@article{Johnston2001PotencyOS,
  title={Potency of select statin drugs in a new mouse model of hyperlipidemia and atherosclerosis.},
  author={Thomas P. Johnston and L. B. Nguyen and Wenjiang Chu and Sarah Shefer},
  journal={International journal of pharmaceutics},
  year={2001},
  volume={229 1-2},
  pages={75-86}
}
Poloxamer-407 (P-407) is a nonionic surfactant that induces atheroma formation in the aortas of C57BL/6 mice with long-term (14 weeks) administration. The objectives of the present study were to determine the mechanism(s) responsible for the induction of hypercholesterolemia as well as to determine whether this animal model may be of potential use in rank ordering the efficacy (lipid lowering) of various statin drugs. The effect of long-term (16 weeks) administration of P-407 on the catalytic… CONTINUE READING