Potency of infused spinal antinociceptive agents is inversely related to magnitude of tolerance after continuous infusion.

@article{Stevens1989PotencyOI,
  title={Potency of infused spinal antinociceptive agents is inversely related to magnitude of tolerance after continuous infusion.},
  author={Craig Stevens and Tony L. Yaksh},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1989},
  volume={250 1},
  pages={1-8}
}
By employing a constant-rate (1 microliter/hr) constant-dose intrathecal infusion pump in rats, groups received a 7-day infusion of one of three concentrations (in nmol/hr) of each of the following receptor preferring ligands: morphine (mu: 2, 6, 20), sufentanil (mu: 0.06, 0.2, 0.6), DAMGO (mu: 0.1, 0.3, 1.0), DADLE (delta: 2, 6, 20) or ST-91 (alpha-2: 3… CONTINUE READING