Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups.

@article{DinkovaKostova2001PotencyOM,
  title={Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups.},
  author={Albena T Dinkova-Kostova and Michael A. Massiah and Richard E Bozak and Ronald J Hicks and Paul Talalay},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 6},
  pages={
          3404-9
        }
}
Induction of phase 2 enzymes and elevations of glutathione are major and sufficient strategies for protecting mammals and their cells against the toxic and carcinogenic effects of electrophiles and reactive forms of oxygen. Inducers belong to nine chemical classes and have few common properties except for their ability to modify sulfhydryl groups by oxidation, reduction, or alkylation. Much evidence suggests that the cellular "sensor" molecule that recognizes the inducers and signals the… CONTINUE READING
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