Potency determination of recombinant IFN-alpha based on phosphorylated STAT1 using flow cytometry.


The interferon (IFN) family of cytokines is recognized as a key component of the innate immune response and the first line of defense against viral infection. The usage of the IFN-alpha as a biopharmaceutical has been mainly applied in the treatment of chronic hepatitis C. In the literature it is possible to find a great variety of methods to determine the… (More)
DOI: 10.1016/j.jim.2011.11.005


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