Potato protease inhibitors inhibit food intake and increase circulating cholecystokinin levels by a trypsin-dependent mechanism

@inproceedings{Komarnytsky2011PotatoPI,
  title={Potato protease inhibitors inhibit food intake and increase circulating cholecystokinin levels by a trypsin-dependent mechanism},
  author={Slavko Komarnytsky and Alison M. Cook and Ilya Raskin},
  booktitle={International Journal of Obesity},
  year={2011}
}
Objective:To investigate the mechanisms underlying the satiety-promoting effects of a novel protease inhibitor concentrate derived from potato (PPIC).Methods:The acute and prolonged effects of oral PPIC administration (100 mg kg−1 per day) on food intake, body weight and gastric emptying were evaluated in healthy rats. Parameters of body weight, food intake, plasma glucose, insulin and cholecystokinin (CCK) were measured. Duodenal proteolytic activity and CCK expression were determined in… CONTINUE READING
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