Potato glycoalkaloids and adverse effects in humans: an ascending dose study.

  title={Potato glycoalkaloids and adverse effects in humans: an ascending dose study.},
  author={Tjeert T. Mensinga and Adrienne J A M Sips and Cathy J. M. Rompelberg and Klaas van Twillert and Jan Meulenbelt and Hester J. van den Top and Hans P. van Egmond},
  journal={Regulatory toxicology and pharmacology : RTP},
  volume={41 1},
Glycoalkaloids in potatoes may induce gastro-intestinal and systemic effects, by cell membrane disruption and acetylcholinesterase inhibition, respectively. The present single dose study was designed to evaluate the toxicity and pharmacokinetics of orally administered potato glycoalkaloids (alpha-chaconine and alpha-solanine). It is the first published human volunteer study were pharmacokinetic data were obtained for more than 24 h post-dose. Subjects (2-3 per treatment) received one of the… CONTINUE READING
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