Potassium leak channels and the KCNK family of two-p-domain subunits

  title={Potassium leak channels and the KCNK family of two-p-domain subunits},
  author={S. A. Goldstein and D. Bockenhauer and I. O'Kelly and N. Zilberberg},
  journal={Nature Reviews Neuroscience},
  • S. A. Goldstein, D. Bockenhauer, +1 author N. Zilberberg
  • Published 2001
  • Physics, Medicine
  • Nature Reviews Neuroscience
  • With a bang, a new family of potassium channels has exploded into view. Although KCNK channels were discovered only five years ago, they already outnumber other channel types. KCNK channels are easy to identify because of their unique structure — they possess two pore-forming domains in each subunit. The new channels function in a most remarkable fashion: they are highly regulated, potassium-selective leak channels. Although leak currents are fundamental to the function of nerves and muscles… CONTINUE READING
    637 Citations

    Figures, Tables, and Topics from this paper

    Explore Further: Topics Discussed in This Paper

    Two-Pore Domain Potassium Channels
    • 24
    Two-Pore-Domain (Kcnk) Potassium Channels: Dynamic Roles in Neuronal Function
    • 139
    Background potassium channels move into focus
    • 3
    Two-Pore Domain Potassium Channels: New Sites of Local Anesthetic Action and Toxicity
    • 67
    Potassium channels: life in the post-structural world.
    • D. Minor
    • Biology, Medicine
    • Current opinion in structural biology
    • 2001
    • 27
    • PDF
    Understanding the cardiac role of K2P channels: a new TASK for electrophysiologists.
    • 7
    • PDF
    Emerging roles for two-pore-domain potassium channels and their potential therapeutic impact.
    • 184
    • Highly Influenced
    Gating of two-pore domain K+ channels by extracellular pH.
    • 18
    • PDF


    Opening and Closing of KcnkØ Potassium Leak Channels Is Tightly Regulated
    • 39
    • PDF
    Kcnkø: single, cloned potassium leak channels are multi-ion pores.
    • 27
    TWIK-2, a New Weak Inward Rectifying Member of the Tandem Pore Domain Potassium Channel Family*
    • 130
    • PDF
    Cloning of a New Mouse Two-P Domain Channel Subunit and a Human Homologue with a Unique Pore Structure*
    • 116
    • PDF
    A mammalian two pore domain mechano‐gated S‐like K+ channel
    • 546
    • PDF
    A functional role for the two-pore domain potassium channel TASK-1 in cerebellar granule neurons.
    • 248
    • PDF