Potassium leak channels and the KCNK family of two-p-domain subunits
@article{Goldstein2001PotassiumLC, title={Potassium leak channels and the KCNK family of two-p-domain subunits}, author={S. A. Goldstein and D. Bockenhauer and I. O'Kelly and N. Zilberberg}, journal={Nature Reviews Neuroscience}, year={2001}, volume={2}, pages={175-184} }
With a bang, a new family of potassium channels has exploded into view. Although KCNK channels were discovered only five years ago, they already outnumber other channel types. KCNK channels are easy to identify because of their unique structure — they possess two pore-forming domains in each subunit. The new channels function in a most remarkable fashion: they are highly regulated, potassium-selective leak channels. Although leak currents are fundamental to the function of nerves and muscles… CONTINUE READING
Figures, Tables, and Topics from this paper
Paper Mentions
637 Citations
Two-Pore-Domain (Kcnk) Potassium Channels: Dynamic Roles in Neuronal Function
- Chemistry, Medicine
- The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
- 2003
- 139
Two-Pore Domain Potassium Channels: New Sites of Local Anesthetic Action and Toxicity
- Medicine
- Regional Anesthesia & Pain Medicine
- 2004
- 67
What have we learned from two-pore potassium channels? Their molecular configuration and function in the human heart
- Chemistry
- 2012
- 2
- PDF
Two-Pore-Domain (K 2P ) Potassium Channels: Leak Conductance Regulators of Excitability
- Chemistry
- 2009
- 10
Potassium channels: life in the post-structural world.
- Biology, Medicine
- Current opinion in structural biology
- 2001
- 27
- PDF
Understanding the cardiac role of K2P channels: a new TASK for electrophysiologists.
- Medicine, Chemistry
- Cardiovascular research
- 2007
- 7
- PDF
Emerging roles for two-pore-domain potassium channels and their potential therapeutic impact.
- Chemistry, Medicine
- Trends in pharmacological sciences
- 2008
- 184
- Highly Influenced
Gating of two-pore domain K+ channels by extracellular pH.
- Chemistry, Medicine
- Biochemical Society transactions
- 2006
- 18
- PDF
References
SHOWING 1-10 OF 147 REFERENCES
Sequence and function of the two P domain potassium channels: implications of an emerging superfamily
- Biology, Medicine
- Journal of Molecular Medicine
- 1998
- 90
Opening and Closing of KcnkØ Potassium Leak Channels Is Tightly Regulated
- Biology, Medicine
- The Journal of general physiology
- 2000
- 39
- PDF
Proton Block and Voltage Gating Are Potassium-dependent in the Cardiac Leak Channel Kcnk3*
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 2000
- 153
- PDF
Kcnkø: single, cloned potassium leak channels are multi-ion pores.
- Chemistry, Medicine
- Biophysical journal
- 2001
- 27
TWIK-2, a New Weak Inward Rectifying Member of the Tandem Pore Domain Potassium Channel Family*
- Biology, Medicine
- The Journal of Biological Chemistry
- 1999
- 130
- PDF
A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem
- Biology, Medicine
- Nature
- 1995
- 404
Cloning of a New Mouse Two-P Domain Channel Subunit and a Human Homologue with a Unique Pore Structure*
- Biology, Medicine
- The Journal of Biological Chemistry
- 1999
- 116
- PDF
A mammalian two pore domain mechano‐gated S‐like K+ channel
- Biology, Medicine
- The EMBO journal
- 1998
- 546
- PDF
A functional role for the two-pore domain potassium channel TASK-1 in cerebellar granule neurons.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 2000
- 248
- PDF