Potassium-induced chloride secretion across the frog retinal pigment epithelium.

@article{Edelman1994PotassiuminducedCS,
  title={Potassium-induced chloride secretion across the frog retinal pigment epithelium.},
  author={Jeffrey L Edelman and Hong Lin and Sheldon Miller},
  journal={The American journal of physiology},
  year={1994},
  volume={266 4 Pt 1},
  pages={
          C957-66
        }
}
In the intact eye, a transition from light to dark increases K concentration ([K]o) from approximately 2 to 5 mM in the extracellular (subretinal) space between the photoreceptors and the retinal pigment epithelium (RPE) apical membrane. In control (HCO3/CO2) Ringer solution, 36Cl was actively absorbed across isolated bullfrog RPE (retina to choroid) at a rate of 0.31 +/- 0.02 (SE) mu eq.cm-2.h-1 (n = 15). Elevating apical [K]o from 2 to 5 mM reversed active 36Cl transport to secretion (choroid… CONTINUE READING

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