Potassium glutamate as a transcriptional inhibitor during bacterial osmoregulation.

  title={Potassium glutamate as a transcriptional inhibitor during bacterial osmoregulation.},
  author={J. D. Gralla and David Romero Vargas},
  journal={The EMBO journal},
  volume={25 7},
Potassium glutamate accumulates upon hyper-osmotic shock and serves as a temporary osmoprotectant. This salt leads to transcriptional activation of sets of genes that allow the cell to achieve long-term adaptation to high osmolarity. The current experiments show that potassium glutamate also acts as an inhibitor of bulk cellular transcription. It can do so independent of the involvement of macromolecular repressors or activators by virtue of its ability to directly inhibit RNA polymerase… CONTINUE READING


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