Potassium dynamics in the epileptic cortex: new insights on an old topic.

  title={Potassium dynamics in the epileptic cortex: new insights on an old topic.},
  author={Flavio Fr{\"o}hlich and Maxim Bazhenov and Vicente J Iragui-Madoz and Terrence J. Sejnowski},
  journal={The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  volume={14 5},
The role of changes in the extracellular potassium concentration [K(+)](o) in epilepsy has remained unclear. Historically, it was hypothesized that [K(+)]( o) is the causal factor for epileptic seizures. This so-called potassium accumulation hypothesis led to substantial debate but subsequently failed to find wide acceptance. However, recent studies on the pathophysiology of tissue from epileptic human patients and animal epilepsy models revealed aberrations in [K(+)](o) regulation… CONTINUE READING

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