Potassium channels mediate killing by human natural killer cells.

  title={Potassium channels mediate killing by human natural killer cells.},
  author={Lyanne C Schlichter and Neil Sidell and Susumu Hagiwara},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={83 2},
Human natural killer (NK) cells in peripheral blood spontaneously recognize and kill a wide variety of target cells. It has been suggested that ion channels are involved in the killing process because there is a Ca-dependent stage and because killings by presensitized cytotoxic T lymphocytes, which in many respects resembles NK killing, is associated with changes in K and Na transport in the target cell. However, no direct evidence exists for ion channels in NK cells or in their target cells… CONTINUE READING


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