Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylation.

@article{White1993PotassiumCS,
  title={Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylation.},
  author={Richard E. White and Arnold Lee and Anatoly Shcherbatko and Thomas Lincoln and Agnes Schonbrunn and David Lee Armstrong},
  journal={Nature},
  year={1993},
  volume={361 6409},
  pages={263-6}
}
Natriuretic peptides inhibit the release and action of many hormones through cyclic guanosine monophosphate (cGMP), but the mechanism of cGMP action is unclear. In frog ventricular muscle and guinea-pig hippocampal neurons, cGMP inhibits voltage-activated Ca2+ currents by stimulating phosphodiesterase activity and reducing intracellular cyclic AMP; however, this mechanism is not involved in the action of cGMP on other channels or on Ca2+ channels in other cells. Natriuretic peptide receptors in… CONTINUE READING

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