Potassium channel blocker dofetilide does not abolish ischaemic preconditioning.

@article{MunchEllingsen1997PotassiumCB,
  title={Potassium channel blocker dofetilide does not abolish ischaemic preconditioning.},
  author={Jens Munch-Ellingsen and Einar Bugge and Jan Eirik L{\o}keb{\o} and Kirsti Ytrehus},
  journal={Scandinavian journal of clinical and laboratory investigation},
  year={1997},
  volume={57 1},
  pages={
          13-20
        }
}
Ischaemic preconditioning (IP) is a powerful mechanism for infarct reduction. Enhanced K+ conductance and shortening of action potential duration in the early phase of the sustained ischaemic episode have been proposed as important factors in the IP mechanism for infarct reduction. We have investigated whether the potassium channel-blocking class III anti-arrhythmic agent dofetilide could abolish IP in an in situ rabbit heart infarct model. Dofetilide is a specific blocker of the delayed… Expand
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