Potassium Dichromate Induced Cytotoxicity, Genotoxicity and Oxidative Stress in Human Liver Carcinoma (HepG2) Cells

@article{Patlolla2009PotassiumDI,
  title={Potassium Dichromate Induced Cytotoxicity, Genotoxicity and Oxidative Stress in Human Liver Carcinoma (HepG2) Cells},
  author={Anita K. Patlolla and Constance Barnes and Diahanna Hackett and Paul B Tchounwou},
  journal={International Journal of Environmental Research and Public Health},
  year={2009},
  volume={6},
  pages={643 - 653}
}
Chromium is a widespread industrial waste. The soluble hexavalent chromium Cr (VI) is an environmental contaminant widely recognized to act as a carcinogen, mutagen and teratogen towards humans and animals. The fate of chromium in the environment is dependent on its oxidation state. Hexavalent chromium primarily enters the cells and undergoes metabolic reduction to trivalent chromium, resulting in the formation of reactive oxygen species together with oxidative tissue damage and a cascade of… CONTINUE READING

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