Corpus ID: 6677219

Potantial utility of disulfiram against leishmaniasis.

@article{Namazi2008PotantialUO,
  title={Potantial utility of disulfiram against leishmaniasis.},
  author={M. Namazi},
  journal={The Indian journal of medical research},
  year={2008},
  volume={127 2},
  pages={
          193-4
        }
}
  • M. Namazi
  • Published 2008
  • Medicine
  • The Indian journal of medical research
The trypanothione biosynthetic pathway, common to the trypanosomatid family of protozoa (which includes Leishmania and Trypanosoma ), is absent in the host systems. This pathway constitutes an important target for chemotherapy against leishmaniasis. The trypanothione pathway combines two metabolic pathways – the polyamine biosynthetic pathway and the glutathione pathway. Since glutathione (GSH) is involved in a number of vital functions within cells, chiefly defence against oxidative damage… Expand
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