Pot1 and cell cycle progression cooperate in telomere length regulation

@article{Churikov2008Pot1AC,
  title={Pot1 and cell cycle progression cooperate in telomere length regulation},
  author={Dmitri Churikov and Carolyn M. Price},
  journal={Nature Structural &Molecular Biology},
  year={2008},
  volume={15},
  pages={79-84}
}
Removal of the vertebrate telomere protein Pot1 results in a DNA damage response and cell cycle arrest. Here we show that loss of chicken Pot1 causes Chk1 activation, and inhibition of Chk1 signaling prevents the cell cycle arrest. However, arrest still occurs after disruption of ATM, which encodes another DNA damage response protein. These results indicate that Pot1 is required to prevent a telomere checkpoint mediated by another such protein, ATR, that is most likely triggered by the G… CONTINUE READING