Pot1 Deficiency Initiates DNA Damage Checkpoint Activation and Aberrant Homologous Recombination at Telomeres

@article{Wu2006Pot1DI,
  title={Pot1 Deficiency Initiates DNA Damage Checkpoint Activation and Aberrant Homologous Recombination at Telomeres},
  author={Ling Wu and Asha S Multani and Hua He and Wilfredo Cosme-Blanco and Yu Deng and Jian Min Deng and Olga Bachilo and Sen Pathak and Hidetoshi Tahara and Susan M. Bailey and Yibin Deng and Richard R. Behringer and Sandy Chang},
  journal={Cell},
  year={2006},
  volume={126},
  pages={49-62}
}
The terminal t-loop structure adopted by mammalian telomeres is thought to prevent telomeres from being recognized as double-stranded DNA breaks by sequestering the 3' single-stranded G-rich overhang from exposure to the DNA damage machinery. The POT1 (protection of telomeres) protein binds the single-stranded overhang and is required for both chromosomal end protection and telomere length regulation. The mouse genome contains two POT1 orthologs, Pot1a and Pot1b. Here we show that conditional… CONTINUE READING
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