Postural changes after lesions of the substantia nigra pars reticulata in hemiparkinsonian monkeys.

@article{Henderson2005PosturalCA,
  title={Postural changes after lesions of the substantia nigra pars reticulata in hemiparkinsonian monkeys.},
  author={Jasmine Monica Henderson and Davor Stanic and Doris Tomas and Justin Patch and Malcolm K. Horne and Darren W. Bourke and David Isaac Finkelstein},
  journal={Behavioural brain research},
  year={2005},
  volume={160 2},
  pages={267-76}
}
Current neurosurgical strategies target overactive brain regions including the subthalamic nucleus, globus pallidus and thalamus to control various symptoms of Parkinson's disease. Subthalamotomy improves akinesia and can induce postural deficits in both parkinsonian humans and animals, pallidotomy improves limb dyskinesia and more variably, distal bradykinesia whilst thalamotomy improves tremor. Because the SNr also becomes overactive in PD and there are few surgical studies in parkinsonian… CONTINUE READING