Postulated role of inter-domain interaction within the ryanodine receptor in Ca(2+) channel regulation.

@article{Ikemoto2000PostulatedRO,
  title={Postulated role of inter-domain interaction within the ryanodine receptor in Ca(2+) channel regulation.},
  author={Noriaki Ikemoto and Takuma Yamamoto},
  journal={Trends in cardiovascular medicine},
  year={2000},
  volume={10 7},
  pages={310-6}
}
Key steps of excitation-contraction (E-C) coupling are (1) binding of the activator portion of the dihydropyridine (DHP) receptor (in skeletal muscle) or binding of the Ca(2+) entered through the DHP receptor (in cardiac muscle) to the ryanodine receptor (RyR), (2) a global protein conformational change of the RyR, and (3) opening of the RyR Ca(2+) channel, leading to muscle contraction. The conformational change (step 2) plays a major role in the Ca(2+) channel regulation, and a number of… CONTINUE READING

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