Posttreatment with high-dose albumin reduces histopathological damage and improves neurological deficit following fluid percussion brain injury in rats.

@article{Belayev1999PosttreatmentWH,
  title={Posttreatment with high-dose albumin reduces histopathological damage and improves neurological deficit following fluid percussion brain injury in rats.},
  author={Ludmila Belayev and Ofelia F. Alonso and Pil Woo Huh and Weizhao Zhao and Raul Busto and Myron D. Ginsberg},
  journal={Journal of neurotrauma},
  year={1999},
  volume={16 6},
  pages={445-53}
}
We have recently shown that high-dose human serum albumin (HSA) therapy confers marked histological protection in experimental middle cerebral artery occlusion. Thus, the purpose of this study was to determine whether treatment with high-dose HSA would protect in a rat model of traumatic brain injury (TBI). Twenty-four hours prior to TBI, the fluid percussion interface was positioned parasagittally over the right cerebral cortex. On the following day, fasted rats were anesthetized with 3… CONTINUE READING
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