Posttraumatic stress disorder and fMRI activation patterns of traumatic memory in patients with borderline personality disorder

  title={Posttraumatic stress disorder and fMRI activation patterns of traumatic memory in patients with borderline personality disorder},
  author={Martin Driessen and T. Beblo and Markus Mertens and Martina Piefke and Nina Rullkoetter and Anamaria Silva-Saavedra and Luise Reddemann and Harald Rau and Hans Joachim Markowitsch and Hella Wulff and Wolfgang Lange and Friedrich G. Woermann},
  journal={Biological Psychiatry},

Figures and Tables from this paper

Early Affective Processing in Patients with Acute Posttraumatic Stress Disorder: Magnetoencephalographic Correlates
The findings indicate that the hypervigilance-avoidance pattern seen in chronic PTSD is not necessarily a product of an endured mental disorder, but arises as an almost immediate result of severe traumatisation.
Functional neuroimaging studies in posttraumatic stress disorder: review of current methods and findings
The findings with regard to PTSD in the functional imaging techniques of single‐photon emission computed tomography, positron emission tomography (PET), and functional magnetic resonance imaging (fMRI) are summarized.
Posterior Midline Activation during Symptom Provocation in Acute Stress Disorder: An fMRI Study
The results suggest that the trauma-related pictures evoke emotionally salient self-referential processing in patients with acute stress disorder shortly after the traumatic event.
Processing of autobiographical memory retrieval cues in borderline personality disorder.
The Neurofunctional Mechanisms of Traumatic and Non-Traumatic Memory in Patients with Acute PTSD Following Accident Trauma
Functional magnetic resonance imaging was used to assess the functional neuroanatomy of emotional memory in surgical patients with acute PTSD to suggest brain circuits affected by the acute disorder are extended and unstable while chronic disease is characterized by circumscribed and stable neurofunctional abnormalities.
Posttraumatic Stress Disorder: The Role of Medial Prefrontal Cortex and Amygdala
  • M. Koenigs, J. Grafman
  • Psychology, Biology
    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2009
Posttraumatic stress disorder (PTSD) is characterized by recurrent distressing memories of an emotionally traumatic event. In this review, the authors present neuroscientific data highlighting the
Current and future functional imaging techniques for post-traumatic stress disorder
The current state of the literature in PTSD, including molecular, cellular, and behavioral indicators, possible biomarkers and clinical and pre-clinical imaging techniques relevant to PTSD, is demonstrated to elucidate the void of current practical imaging and spectroscopy methods that provide true biomarkers for the disorder and the significance of devising new techniques for future investigations.
Increased white matter integrity of posterior cingulate gyrus in the evolution of post-traumatic stress disorder
Findings suggest that alterations of white matter integrity in PCG link to mnemonic and affective processing in PTSD over the long-term follow-up period.
In Search of the Trauma Memory: A Meta-Analysis of Functional Neuroimaging Studies of Symptom Provocation in Posttraumatic Stress Disorder (PTSD)
PTSD patients showed significantly less activation than controls in sensory association areas such as the bilateral temporal gyri and extrastriate area which may indicate that the patients’ attention was diverted from the presented stimuli by being focused on the elicited trauma memory.
Functional MRI correlates of the recall of unresolved life events in borderline personality disorder
The activation of both, the amygdala and prefrontal areas, might reflect an increased effortful but insufficient attempt to control intensive emotions during the recall of unresolved life events in patients with BPD.


Recall of emotional states in posttraumatic stress disorder: an fMRI investigation
Neural correlates of traumatic memories in posttraumatic stress disorder: a functional MRI investigation.
The findings suggest anterior cingulate, frontal, and thalamic involvement in the neuronal circuitry underlying PTSD.
Magnetic resonance imaging volumes of the hippocampus and the amygdala in women with borderline personality disorder and early traumatization.
In female patients with BPD, the authors found reduction of the volumes of the hippocampus (and perhaps of the amygdala), but the association of volume reduction and traumatic experiences remains unclear.
A symptom provocation study of posttraumatic stress disorder using positron emission tomography and script-driven imagery.
The results suggest that emotions associated with the PTSD symptomatic state are mediated by the limbic and paralimbic systems within the right hemisphere.
Evidence of abnormal amygdala functioning in borderline personality disorder: a functional MRI study
Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD: A PET investigation.
The recollection and imagery of traumatic events versus neutral events was accompanied by regional CBF increases in anterior paralimbic regions of the brain in trauma-exposed individuals with and without posttraumatic stress disorder.
Visual imagery and perception in posttraumatic stress disorder. A positron emission tomographic investigation.
Results suggest that ventral anterior cingulate gyrus and right amygdala play a role in the response of combat veterans with PTSD to mental images of combat-related scenes.