Posttraumatic stress disorder: the role of medial prefrontal cortex and amygdala.

  title={Posttraumatic stress disorder: the role of medial prefrontal cortex and amygdala.},
  author={Michael Koenigs and Jordan Grafman},
  journal={The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  volume={15 5},
Posttraumatic stress disorder (PTSD) is characterized by recurrent distressing memories of an emotionally traumatic event. In this review, the authors present neuroscientific data highlighting the function of two brain areas--the amygdala and ventromedial prefrontal cortex (vmPFC)--in PTSD and related emotional processes. A convergent body of human and nonhuman studies suggests that the amygdala mediates the acquisition and expression of conditioned fear and the enhancement of emotional memory… CONTINUE READING
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