Posttransplant bronchiolitis obliterans syndrome is associated with bronchial epithelial to mesenchymal transition.

@article{Hodge2009PosttransplantBO,
  title={Posttransplant bronchiolitis obliterans syndrome is associated with bronchial epithelial to mesenchymal transition.},
  author={Sandra Hodge and Mark Holmes and Balarka Banerjee and Michael Musk and Anthony Kicic and Grant Waterer and Paul N. Reynolds and Greg Hodge and Daniel C Chambers},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2009},
  volume={9 4},
  pages={727-33}
}
Bronchiolitis obliterans syndrome (BOS) compromises lung transplant outcomes and is characterised by airway epithelial damage and fibrosis. The process whereby the normal epithelial configuration is replaced by fibroblastic scar tissue is poorly understood, but recent studies have implicated epithelial mesenchymal transition (EMT). The primary aim of this study was to assess the utility of flow cytometry in detecting and quantifying EMT in bronchial epithelial cells. Large airway brushings were… CONTINUE READING

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