Posttransplant HLA alloreactivity in stable kidney transplant recipients-incidences and impact on long-term allograft outcomes.

@article{Bartel2008PosttransplantHA,
  title={Posttransplant HLA alloreactivity in stable kidney transplant recipients-incidences and impact on long-term allograft outcomes.},
  author={Gregor Bartel and Heinz M Regele and Markus Wahrmann and Nicole Huttary and Markus Exner and Walter Hermann H{\"o}rl and Georg A B{\"o}hmig},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2008},
  volume={8 12},
  pages={2652-60}
}
Humoral alloreactivity is well established to predict adverse allograft outcomes. However, in some recipients, alloantibodies may also occur in the absence of graft dysfunction. We evaluated if and how often complement- and noncomplement-fixing alloantibodies are detectable in stable recipients and whether, in this context, they affect long-term outcomes. Sera obtained from 164 kidney transplant recipients at 2, 6 and 12 months were evaluated by FlowPRA screening and single-antigen testing for… CONTINUE READING

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