Posttranslational regulation of the retinoblastoma gene family member p107 by calpain protease

Abstract

The retinoblastoma protein plays a critical role in regulating the G1/S transition. Less is known about the function and regulation of the homologous pocket protein p107. Here we present evidence for the posttranslational regulation of p107 by the Ca2+-activated protease calpain. Three negative growth regulators, the HMG-CoA reductase inhibitor lovastatin… (More)
DOI: 10.1038/sj.onc.1202497

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