Posttranslational regulation of thioredoxin-interacting protein.

@article{Robinson2012PosttranslationalRO,
  title={Posttranslational regulation of thioredoxin-interacting protein.},
  author={K. A. Robinson and Jonathan W. C. Brock and M. Buse},
  journal={Journal of molecular endocrinology},
  year={2012},
  volume={50 1},
  pages={
          59-71
        }
}
Thioredoxin-interacting protein (Txnip) is a metabolic regulator, which modulates insulin sensitivity and likely plays a role in type 2 diabetes. We studied the regulation of Txnip in 3T3-L1 adipocytes. Cells were incubated under different conditions and Txnip was measured by immunoblotting. We confirmed that high glucose markedly increases Txnip expression by promoting transcription. Insulin decreases Txnip protein levels. Rapamycin under most conditions decreased Txnip, suggesting that mTOR… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 35 REFERENCES

TXNIP Regulates Peripheral Glucose Metabolism in Humans

  • PLoS medicine
  • 2007
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…