Posttranslational regulation of keratins: degradation of mouse and human keratins 18 and 8.

@article{Kulesh1989PosttranslationalRO,
  title={Posttranslational regulation of keratins: degradation of mouse and human keratins 18 and 8.},
  author={D A Kulesh and Grace Cecena and Yves Michel Darmon and Marc Vasseur and Robert G. Oshima},
  journal={Molecular and cellular biology},
  year={1989},
  volume={9 4},
  pages={
          1553-65
        }
}
Human keratin 18 (K18) and keratin 8 (K8) and their mouse homologs, Endo B and Endo A, respectively, are expressed in adult mice primarily in a variety of simple epithelial cell types in which they are normally found in equal amounts within the intermediate filament cytoskeleton. Expression of K18 alone in mouse L cells or NIH 3T3 fibroblasts from either the gene or a cDNA expression vector results in K18 protein which is degraded relatively rapidly without the formation of filaments. A K8 cDNA… CONTINUE READING
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