Posttranslational regulation of Bim by caspase-3.

  title={Posttranslational regulation of Bim by caspase-3.},
  author={Hidetoshi Wakeyama and Toru Akiyama and Yuho Kadono and Masaki Nakamura and Yasushi Oshima and Kozo Nakamura and Sakae Tanaka},
  journal={Annals of the New York Academy of Sciences},
Bim is a proapoptotic BH3-domain-only member of the Bcl-2 family, and its expression is regulated both transcriptionally and posttranslationally. We developed an in vitro system examining the posttranslational regulation of Bim. Since Bim is a strong mediator of apoptosis, it has been quite difficult to establish cell lines stably overexpressing Bim. Coexpression of Bcl-2 enabled us to obtain mouse embryonic fibroblasts (MEFs) in which Bim is overexpressed and Bcl-2 expression is regulated by… CONTINUE READING

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