Posttranslational processing of human and mouse urocortin 2: characterization and bioactivity of gene products.

@article{Vaughan2013PosttranslationalPO,
  title={Posttranslational processing of human and mouse urocortin 2: characterization and bioactivity of gene products.},
  author={Joan M. Vaughan and Cynthia J. Donaldson and Wolfgang K. Fischer and Marilyn H. Perrin and Jean E F Rivier and Paul E Sawchenko and Wylie W. Vale},
  journal={Endocrinology},
  year={2013},
  volume={154 4},
  pages={1553-64}
}
Mouse (m) and human (h) urocortin 2 (Ucn 2) were identified by molecular cloning strategies and the primary sequence of their mature forms postulated by analogy to closely related members of the corticotropin-releasing factor (CRF) neuropeptide family. Because of the paucity of Ucn 2 proteins in native tissues, skin, muscle, and pancreatic cell lines were transduced with lentiviral constructs and secretion media were used to isolate and characterize Ucn 2 products and study processing. Primary… CONTINUE READING